Thopil Bhasi - Malayalam playwright, screenwriter, and film director
Dr. K. M. Cherian - heart surgeon; founder of Frontier Lifeline Hospital
Kambisseri Karunakaran - journalist, politician, actor, satirist and rationalist
P. Kesavadev - novelist and social reformer
Kayamkulam Kochunni - highwayman based in Kayamkulam, active in Central Travancore in the early 19th century
K. P. A. C. Lalitha - National Award-winning Indian film and stage actress
B. S. Manoj - Author, Academician, and Scientist
Prof. S. Guptan Nair - Malayalam writer, critic, scholar and educationist
P. Padmarajan - author, screenwriter, and film director
Advocate Achutha Warrier - politician, Communist leader, Co-operative movement organizer, Social activist .
Muthukulam Raghavan Pillai - dramatist, poet, screenplay writer and actor
Resul Pookutty - Oscar-winning Indian film sound designer, sound editor and mixer
Thachadi Prabhakaran - former Minister of Kerala
Cartoonist Shankar (K. Shankara Pillai) - founder of Shankar's Weekly
Kayamkulam Philipose Ramban - Christian priest; lived in Kayamkulam in the 19th century
T. P. Sreenivasan - diplomat; former High Commissioner to Fiji and Kenya and Ambassador to Austria
Dr.Cheravally Sasi - Malayalam poet, lyricist and historian who is the author of 'Odanadinte Ulthudipukal'
Eruvayil Atchutha Warrier - Commander in Chief of Kayamkulam Rajyam, Prime Minister of Kayamkulam .