Kayamkulam is well connected by road and rail network. Besides this, Alappuzha-Kollam boat service runs via Kayamkulam city. 

Roads

NH66 passes through Kayamkulam, which conveniently connects it to the major cities Alappuzha, Kochi, Thiruvananthapuram, Thrissur, Kollam, Palakkad and Nagercoil. The Kayamkulam-Punalur (KP) road is a major road connecting it to the eastern parts of the State. The KSRTC Bus Station[code KYLM] lies very near to the national highway and is one of the biggest bus stations of KSRTC in terms of total area. All the KSRTC buses have halt at Kayamkulam Bus station. The new Railway Terminal Bus Stand near Kayamkulam Railway Station is an interlink between railway and road transport.

Railways

Kayamkulam Junction railway station(Kayankulam Jn) [code KYJ] is a major railway junction situated 1.5 km from the town on the K.P. Road. Trains from the North from Ernakulam via Kottayam, and from Ernakulam via Alappuzha pass through Kayamkulam Junction and then proceed to Kollam, Thiruvananthapuram and further to Nagercoil and Kanyakumari.