Road
Wadakkanchery is situated on the Thrissur–Shoranur State Highway 22 and is directly connected to Kunnamkulam (another major town in the Thrissur district). Ottupara Bus Stand is a main stop on the Thrissur–Ottapalam/chelakkara bus route. There has been a huge demand for the last many years to make Thrissur–Perinthalmanna–Nilambur–Ooty or Bangalore a National Highway. Wadakkanchery is the endpoint of State Highway 50 that connects the town to Chavakkad and Guruvayoor via Kunnamkulam.

Rail
Wadakanchery Railway Station (alternatively spelled Wadakancheri Railway Station; station code WKI) is located in Wadakancherry and is managed by Southern Railways. Being one status of adarsh station by the government of India, it is the main station after Thrissur Railway station. It has two platforms. Most express trains stop here.

Air
The nearest airports are Cochin International Airport (Nedumabassery airport; code COK), at a distance of 70 km, and Calicut International Airport (Code CCJ).