The religious harmony of the place is evident as one can see the churches, temples and mosques situated close to each other. Thalayolaparambu is home for eight Hindu Temples, four Churches and two Mosques. These places hosts ancient and modern artworks. Tourists from all over the world are attracted to these places.

The four churches in Thalayolaparambu are St. George Church, St. Michael's Church, Infant Jesus Church and St. Antony's Church. St. George Church, Thalayolaparambu is an important Catholic church in Kerala. This church is situated beside the Kottayam – Ernakulam road at Pallikavala junction, Thalayolaparambu. The reconstructed church was inaugurated by Cardinal Joseph Parecattil on 31 December 1972 which was apparently the same day of the centenary remembrance of St. Thomas.

Among the temples in Thalayolaparambu Pundareekapuram temple is famous for its wall paintings. The walls of the sanctum sanctorum of the temple are covered with exquisite paintings which depict episodes from the Hindu myths and Puranas. The murals in this temple are some of the best in Kerala. It is situated in Midayikunnam. Sree Krishna temple, Sree Mathanam Bhagavathi temple, Sree Karthyayani Devi temple, Sree Elamkavu Devi temple, Thrikkarayikkulam Mahadeva temple, Pothy Mahavishnu temple, Pattupurackal Devi temple and Palamkadavu Sree Durga Devatha temple are also located in this area.

Another important cultural feature of this region is the annual festival (Attuvela) hosted by the Vadayar Ilamkavu temple. A procession is done through the Muvattupuzha river as part of the festival. The main attraction of the procession is the three storied artifact specially made in large barges for the event. These barges are part of the procession which held at night. All the boats will be decorated using electric lights. This festival attracts a lot of tourists including people from across the world.

Mohiyudheen masjid situated in the market is one of the important mosques in this locality. History of this mosque goes back to centuries. The pillars and the artwork inside the mosque reflects traditional Kerala architecture. The whole building reminds a traditional 'nalukettu'. Other mosques in this locality includes Vettikkattumukku Juma Masjid, Salafi Masjid, Sainudheen thangal thaikavu, and Palankadavu thaikavu. There are madrasas functioning in Thalayolaparambu, Palamkadavu and Vettikkattumukku. Vaikom Muhammed Basheer did his religious schooling in the madrasa at Palankadavu.