It is mentioned in many literary works of Sangha period like "Pathittupathu" that Kadampanad was a part of ancient Tamil Nadu. The beautiful architecture of Parakkadavu snanaghatas and kalmandapas, built on the banks of Kallada river, in connection with the Pazhayakavu and Puthiyakavu devi temple of Mannadi are proofs of ancient civilization in this place. Kadampanad was a trade center in the ancient period. Under the Kulashekhara kings, who ruled Travancore with Mahodayapuram as their headquarters, there were many autonomous provinces. Kadampanad was such a province under the control of a Naduvazhi. After the decline of Kulasekhara reign, Kadampanad came under the rule of Venad Kings. Later, Kadamapanad became the part of Kayamkulam territory and when Marthanda Varma formed modern Travancore, it fell under this region. When Sir C.P. Ramaswamy Iyyer was the Divan of Central Travancore, Village uplift unions were formed for the development of villages in Kerala. The village uplift unions were composed of Government nominated representatives. The places come under Kadampanad grama panchayath were part of Kunnathur uplift union at that time. Thonnuram Panthiyil K. Kesavakurup was the president of Kunnathur uplift union. In 1953, when panchayaths formed, panchayath bodies elected by people came into being. The first president of the elected body of Kadampanad panchayath was Koyippurath K. Neelakandan Nair. After the formation of Kerala State, Kadampanad panchayath continued to be a part of Kollam district, under Kunnathur Taluk. In 1983, when Pathanamthitta district was formed, Kadampanad panchayath became a part of it.

St. Thomas Orthodox Cathedral (Kadampanad Church), one of the most prominent churches of the Malankara Orthodox community is situated in Kadampanad Panchayat. Christians from this parish migrated to places like Kayamkulam, Mavelikkara, Kollakadavu, Adoor, Thuvayoor, Kozhenchery, Kaippattoor, Sooranadu, Kallada, Koodal etc., settled there and constructed new churches.[7] Hence this church is considered to be the mother parish of many churches in Central Travancore. St. John’s Orthodox Syrian Church Thuvayoor, St. George Malankara Catholic Church, Shalom Marthoma Church, St. Andrew's Marthoma Church, '''St. Mary's orthodox church kadampanad north''', St. Thomas Catholic Church, St. Mary’s Catholic Church, St. Thomas Marthoma Church, St. Peter's Marthoma Church, Lourdes Matha Church and St. James CSI Church are the other Christian devotional centres in this panchayath.The Church of God at Thuvayoor is the first Pentecostal church in Kerala. The Jama-ath mosques in Mannadi and Nilakkal are also part of the diverse culture of this place.The Kadampanad Bhagavathy Temple and the Kundom Vettuthu Malanada temple, the Maharshi Mangalam temple in Thuvayoor, the Kannankara Yakshi temple in Manjali junction, the Mudippura Devi temple, Pazhayakavu and Puthiyakavu Devi temples in Mannadi are the important temples in Kadampanad Panchayath. Kadampanad panchayath consists of 8 other temples also.